Database : HANSEN Search on : ANEMIA HEMOLITICA/ETIOL [Subject descriptor] References found : 3 [refine] Displaying: 1 .. 3   in format [Detailed]

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Id: 18103 Author: Desforges, J. F; Thayer, W. W; Dawson, J. P Title: Hemolytic anemia induced by sulfoxone therapy, with investigations into the mechanisms of its production ?- Source: Boston; s.n; 1960. 5p p. ilus. Abstract: A case report is presented of a patient in whom clinical evidence of hemolytic anemia with methemoglobinemia developed upon increasing the dosage of sulfoxone which he was receiving for Hansen's disease. Administration of the drug was withdrawn for six weeks, after which studies were made with the use of radioactive iron to demosntrate the hemolytic effect of sulfoxone. By means of tagging cells of a single age group, it was shown that the suceptibility to hemolysis was related to cell age, and it was only after the red cells had been in the circulation for approximately fifty days that they were subject to the hemolytic effects of this drug. No significant biochemical defect could be demonstrated in the erythrocytes of this patient. However, the decline in activity of glucose-6-phosphate dehydrogenase and glutathione reductase in the aging red cell and the reported sensitivity to this drug of patients with red cell deficiency of glucose-6-phosphate dehydrogenase suggest that the hemolytic mechanism is related to this enzyme system. The case demonstrates that drug-induced hemolytic anemia of this type may occur without demonstrable enzymatic defect of the erythrocytes. The observation that patients appear to compensate for the hemolytic anemia and methemoglobinemia if maintained on this drug may be explained by the fact that the older cells containing less adequate enzyme systems are removed from the circulation and an equilibrium is maintained by increased production of red cells with a shorter age span. Descriptors: HANSENOSTATICOS/admin HANSENOSTATICOS/ef adv HANSENOSTATICOS/sangue HANSENOSTATICOS/uso terap ANEMIA HEMOLITICA/ind quim ANEMIA HEMOLITICA/diag ANEMIA HEMOLITICA/etiol - HANSENIASE/clas  HANSENIASE/compl  HANSENIASE/diag  HANSENIASE/terap Limits: RELATO DE CASO Location: BR191.1; 00720/s

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Id: 13444 Author: Tomecki, Kenneth J; Catalano, Charles J Title: Dapsone hypersensitivity ..- Source: s.l; s.n; jan. 1981. 2 p. . Abstract: A hypersensitivity reaction to low-dose (50-mg), short-term dapsone administration developed in a 16-year-old girl. The reaction included fever, malaise, dermatitis, jaundice with hepatic dysfunction, lymphadenopathy, and hemolytic anemia. Physicians should be familiar with this sulfone syndrome, an uncommon, potentially serious, side effect of dapsone therapy.(AU). Descriptors: ACNE VULGAR/quimioter ANEMIA HEMOLITICA/etiol DAPSONA/ef adv ERUPCAO POR DROGA/etiol HIPERSENSIBILIDADE A DROGAS/diag HEPATITE TOXICA/etiol DOENCAS LINFATICAS/ind quim SINDROME Limits: RELATO DE CASO HUMANO FEMININO ADOLESCENTE Electronic Medium: http://www.ilsl.br Location: BR191.1; 00741/s

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Id: 13263 Author: Tomecki, Kenneth J; Catalano, Charles J Title: Dapsone hypersensitivity ..- Source: s.l; s.n; jan. 1981. 2 p. . Abstract: A hypersensitivity reaction to low-dose (50-mg), short-term dapsone administration developed in a 16-year-old girl. The reaction included fever, malaise, dermatitis, jaundice with hepatic dysfunction, lymphadenopathy, and hemolytic anemia. Physicians should be familiar with this sulfone syndrome, an uncommon, potentially serious, side effect of dapsone therapy.(AU). Descriptors: ACNE VULGAR/quimioter ANEMIA HEMOLITICA/etiol DAPSONA/ef adv ERUPCAO POR DROGA/etiol HIPERSENSIBILIDADE A DROGAS/diag HEPATITE TOXICA/etiol DOENCAS LINFATICAS/ind quim SINDROME Limits: RELATO DE CASO HUMANO FEMININO ADOLESCENTE Electronic Medium: http://www.ilsl.br Location: BR191.1; 00724/s

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